- 5× Pro Bowl (2007, 2008, 2009, 2010, 2011)
- 2× First-team All-Pro (2008, 2010)
- 2× Second-team All-Pro (2007, 2009)
- 2× Super Bowl champion (XL, XLIII)
- 3× AFC Champion (2005, 2008, 2010)
- AP NFL Defensive Player of the Year (2008)
- AFC Defensive Player of the Year (2008)
- Tuesday Morning Quarterback Non-QB Non-RB NFL MVP Award (2008)
- GMC Sierra Defensive Player of the Year Winner (2008)
- 2× Pittsburgh Steelers Team MVP (2007, 2008)
- 2× AFC Defensive Player of the Month (November 2007, October 2009)
- Longest interception in Super Bowl history – 100-yards (2nd longest in game’s history)
- Ranked # 21 on The NFL Top 100 players of 2011
- Ranked # 29 on The NFL Top 100 players of 2012